In this paper, a new method based on the combination of the Teaching-learning-based-optimization (TLBO) and Black-hole (BH) algorithm has been proposed for the reconfiguration of distribution networks in order to reduce active power losses and improve voltage profile in the presence of distributed generation sources. The proposed method is applied to the IEEE 33-bus radial distribution system. The results show that the proposed method can be a very promising potential method for solving the reconfiguration problem in distribution systems and has a significant effect on loss reduction and voltage profile improvement.