Transmitting binary data across a network should generally avoid transmitting raw binary data over the medium for several reasons, one would be that the medium may be a textual one and may not accept or correctly handle raw bitstream, another would be that some protocols may misinterpret the meaning of the bits and causes a problem or even loss of the data. To make the data more readable and would avoid misinterpretation by different systems and environments, this paper introduces encoding two of the most broadly used data interchange formats, XML and JSON, into the Base64 which is an encoding scheme that converts binary data to an ASCII string format by using a radix-64 representation. This process, will, make the data more readable and would avoid misinterpretation by different systems and environments. The results reflect that encoding data in Base64 before the transmission will present many advantages including readability and integrity, it will also enable us to transmit binary data over textual mediums, 7 Bit protocols such as SMTP, and different network hardware without risking misinterpretation.